Our Treatment Programs

Advanced Treatment Programs for
Chronic Lyme Disease in Tijuana

Three medically supervised outpatient programs, each targeting a critical layer of chronic Lyme disease recovery. Delivered within the Immunotherapy Institute — Tijuana's leading advanced immunotherapy center. Programs can be completed individually or combined. All include daily physician oversight and personalized care.

6-Day OutpatientImmune Regulation

Advanced Autologous T-Regulatory (Treg) Cell Therapy

Patient receiving Treg cell therapy at Lyme Immunotherapy Center Autologous Regulatory T-Cell Therapy infographic

Designed for patients with chronic Lyme disease and associated co-infections particularly experiencing persistent symptoms driven by immune dysregulation. In chronic Lyme, the master switch governing Treg function (FOXP3) becomes unstable, leaving the immune system overactive, misdirected, and without an effective brake — driving ongoing inflammation, flares, and treatment resistance.

With more than 15 years of experience in autologous immunotherapy and as the first center to bring this approach to chronic Lyme disease patients, our team has developed and refined this protocol specifically for the immune dysregulation patterns of Lyme disease. The therapy collects your own T cells, engineers them with a stabilized FOXP3, stress-tests them in laboratory conditions replicating your chronic inflammatory environment, selects only resilient cells, then expands and reinfuses them to restore immune regulation at the source.

What's included

  • 3 applications of autologous Treg (Regulatory T-cell) therapy
  • Daily consultations with functional medicine physicians (MDs)
  • Epigenetic testing for personalized insight
  • Initial bloodwork and comprehensive medical evaluation
  • Consultation with a clinical nutritionist
  • 6-day outpatient care with daily physician oversight

Treatment phases

Phase 1
Assessment & preparation Bloodwork, epigenetic testing, immune evaluation, and initial physician consultation to establish baseline and guide personalization.
Phase 2
Immune modulation 3 applications of autologous Treg therapy with ongoing physician monitoring. Focused on restoring immune balance and regulation.
Phase 3
Support & stabilization Nutritional guidance, functional medicine oversight, and personalized recommendations to reinforce immune changes.

Who this program is for

  • Chronic Lyme disease with persistent multi-system symptoms
  • Prior antibiotic treatment with incomplete or no resolution
  • Symptom pattern of flares, immune overreaction, and treatment sensitivity
  • Co-infections present or suspected (Babesia, Bartonella, EBV)
  • Seeking a more advanced immune-focused approach

Learn more: What is Treg therapy for Lyme disease · Why Lyme patients lose immune regulation · How Treg therapy resets the immune system

Is this program right for you?

Every treatment plan is built around your specific case — your history, your co-infections, your immune profile. Our case manager will review your intake personally and outline what a program would look like for you.

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5-Day OutpatientDetox + Pathogen Targeting

Systemic Perfusion Hyperthermia & Therapeutic Apheresis

Systemic perfusion hyperthermia for Lyme disease Therapeutic apheresis patient treatment

For patients who feel "stuck" — where prior treatments have stopped working and symptoms persist. This program combines blood filtration to reset the internal environment with controlled thermal therapy to target heat-sensitive pathogens simultaneously.

Therapeutic Apheresis

A specialized blood filtration process that removes inflammatory cytokines, circulating toxins, immune complexes, and heavy metals directly from the bloodstream — resetting the internal environment and making the body more receptive to all subsequent therapies.

Systemic Perfusion Hyperthermia

Raises core body temperature to 41–42°C under continuous medical monitoring. Borrelia and co-infections are highly heat-sensitive — this therapy destabilizes their biofilms, makes dormant organisms vulnerable, stimulates immune activation, and improves circulation and tissue perfusion.

What's included

  • Therapeutic Apheresis — blood filtration and internal environment reset
  • Systemic Perfusion Hyperthermia under strict medical supervision
  • Epigenetic testing and advanced personalization
  • Daily physician monitoring and oversight
  • Nutritional guidance tailored to detoxification and recovery

Why combining both matters

Apheresis first clears the toxic and inflammatory burden — removing the cytokines, immune complexes, and debris that prevent the body from responding. Hyperthermia then applies controlled thermal stress to pathogens that the cleaner internal environment is now better positioned to address. The sequence is deliberate: each step prepares the ground for the next.

Who this program is for

  • Chronic Lyme patients who feel "stuck" — where prior treatments have stopped working
  • High inflammatory burden with fatigue, brain fog, and systemic discomfort
  • Patients who need to reduce toxic and inflammatory load before immune therapies
  • Co-infections (Babesia, Bartonella) driving persistent pathogen burden

Learn more: What is systemic perfusion hyperthermia for Lyme disease · How apheresis clears the inflammatory burden of Lyme disease

Is this program right for you?

Treatment is never one-size-fits-all. Our case manager reviews each patient individually to determine whether this program is appropriate and what it would involve for your specific situation.

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18-Day ComprehensiveFull Protocol

Comprehensive 18-Day Lyme Treatment Protocol

IV therapy room at Lyme Immunotherapy Center Tijuana Mexico

Our most complete program — designed for patients with chronic or complex Lyme disease who need a full, multi-system approach. Rather than relying on a single intervention, this protocol combines the most advanced medical therapies with supportive, personalized care. Assessment informs treatment. Treatment is reinforced by nutrition, physiotherapy, and psychological support. Every element is personalized to your biology.

Advanced therapeutic technologies

  • Autologous T-Regulatory (Treg) Cell Therapy
  • Systemic Perfusion Hyperthermia
  • Whole-Body Hyperthermia (Heckel Technology)
  • Therapeutic Apheresis
  • Systemic Ozone Auto-Hemotherapy
  • Electro-Conductive Hyperthermia
  • Transdermal Ozone Therapy

IV Therapy — organized by treatment lane

Lane 1 · Inflammation Control
Curcumin IV
Inhibits NF-kB and inflammatory cytokines driving Lyme symptoms.
Alpha Lipoic Acid IV
Crosses the blood-brain barrier; addresses neuroinflammation and mitochondrial function.
Chelation Plus IV
Removes heavy metals and disrupts microbial biofilms protecting persistent organisms.
Lane 2 · Antioxidant & Recovery
Glutathione IV
Master antioxidant — severely depleted in chronic Lyme; critical for cellular defense and detox.
Vitamin C IV
Pharmacological-dose antioxidant with direct immune modulation and antimicrobial properties.
Selenium IV
Essential for glutathione enzyme systems, thyroid function, and T cell regulation.
Lane 3 · Nervous System
Magnesium Chloride IV
Depleted in chronic Lyme; addresses muscle pain, sleep disruption, and nervous system hyperreactivity.
Phosphatidylcholine IV
Rebuilds cell membrane integrity and supports neurological recovery and detox capacity.
Riboflavin (B2) · Procaine IV
Cellular energy pathways and pain-sensitivity regulation.

Supportive services included

  • 3 personalized therapeutic meals per day (detox-aligned nutrition)
  • Roundtrip airport and clinic transportation
  • Physiotherapy tailored to pain, fatigue, and mobility
  • Psychological support for the emotional toll of chronic illness
  • Nutrition counseling for mitochondrial function and detox
  • Comprehensive lab panel and epigenetic analysis

Learn more: Why the combined protocol works · How immunotherapy breaks the chronic inflammation cycle · What patients experience after treatment

Is this program right for you?

This is our most comprehensive protocol, designed for patients with complex or longstanding Lyme disease who need a full multi-system approach. Our case manager will review your case and discuss what the program would involve for you specifically.

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Common questions about our programs

T-Regulatory Cell (Treg) therapy is an autologous immunotherapy that uses your own T cells, engineers them with a stabilized FOXP3 gene, and reinfuses them to restore the immune regulation that chronic Lyme disease systematically destroys. Unlike antibiotics or anti-inflammatory drugs, Treg therapy addresses the broken regulatory mechanism at the center of chronic Lyme immune dysfunction — not just its downstream symptoms.
Systemic Perfusion Hyperthermia (SPH) is a hospital-based procedure that raises core body temperature to 41–42°C under continuous medical monitoring. Borrelia burgdorferi and many Lyme co-infections are highly heat-sensitive — at therapeutic temperatures, their protein architecture breaks down, biofilm communities are disrupted, and dormant organisms become vulnerable. SPH also stimulates immune activation and improves tissue perfusion. It is performed under anesthesia with full vital sign monitoring throughout.
Therapeutic apheresis is a blood filtration procedure that removes pro-inflammatory cytokines (IL-6, TNF-alpha), circulating immune complexes, autoantibodies, bacterial debris, heavy metals, and other inflammatory mediators from the bloodstream. In chronic Lyme patients, these substances accumulate over years and perpetuate immune dysfunction even when pathogen load is reduced. Apheresis removes this inflammatory burden directly, creating a cleaner internal environment for subsequent immune therapies.
Treatment investment depends on the program and your individualized plan — because no two patients receive exactly the same protocol, costs are discussed personally after your case has been reviewed. What we can say: comparable advanced integrative Lyme programs at clinics in the United States, Germany, or Switzerland typically cost significantly more than equivalent treatment in Tijuana. Our case manager will walk you through what to expect during your eligibility consultation.
The clinic is located in Tijuana, Mexico, approximately 30–45 minutes from San Diego International Airport. We arrange roundtrip transportation for all patients. The most common route is to fly into San Diego (SAN) and cross via the Otay Mesa or San Ysidro border crossing — both are straightforward and well-traveled routes for US patients seeking medical care in Tijuana.
The right program depends on your clinical profile. Patients with strong immune dysregulation as the primary driver often start with the 6-Day Treg Program. Patients with high inflammatory and toxic burden, or where prior treatments have stopped working, often benefit most from starting with the 5-Day SPH & Apheresis Program. The 18-Day Protocol is designed for patients with complex or longstanding Lyme who need the full multi-system approach. Our case manager reviews each patient individually before recommending a program.
Yes. The 18-Day Comprehensive Protocol already combines all three core therapies — Treg, hyperthermia, and apheresis — in a coordinated sequence. Patients who complete the 5-Day or 6-Day program sometimes return for a second program to address additional dimensions of their condition. Our team will discuss what makes sense for your individual case during the eligibility review.
Accommodations

Recommended Lodging — Quartz Hotel & Spa ★★★★★

We recommend staying at Quartz Hotel & Spa — a 5-star Medical Tourism Hotel in Tijuana designed around holistic wellness. Our patients receive a preferred rate. P.º del Centenario 4210, Zona Urbana Rio Tijuana · +52 (664) 862 8200